Longitudinal Magnetization Transfer Imaging in Mild to Severe Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Longitudinal magnetization transfer imaging in mild to severe Alzheimer disease.
BACKGROUND AND PURPOSE MTI has been proposed as a sensitive technique for studying microstructural brain tissue changes in patients with AD, but the course of these changes over time is largely unknown. We therefore used a placebo-controlled study of memantine to follow the evolution of tissue damage in AD by means of MTR measurements and investigated how MTR changes were related to brain atrop...
متن کاملClassification of mild cognitive impairment and Alzheimer disease using model-based MR and magnetization transfer imaging.
BACKGROUND AND PURPOSE Early stratification of degenerative processes is a prerequisite to warrant therapeutic options in prodromal Alzheimer disease. Our aim was to investigate differences in cerebral macromolecular tissue composition between patients with AD, mild cognitive impairment, and age- and sex-matched healthy controls by using model-based magnetization transfer with a binary spin-bat...
متن کاملLongitudinal multimodal imaging in mild to moderate Alzheimer disease: a pilot study with memantine
OBJECTIVE To study the feasibility of multimodal neuroimaging in mild to moderate Alzheimer disease (AD) and to estimate the size of possible treatment effects of memantine on potential functional, structural and metabolic biomarkers of disease progression. METHODS In this randomised, double-blind, placebo-controlled pilot study, 36 patients with moderate AD received 52 weeks of memantine (20...
متن کاملMagnetization transfer ratio in Alzheimer disease: comparison with volumetric measurements.
BACKGROUND AND PURPOSE Alzheimer disease (AD) is accompanied by macroscopic atrophy on volumetric MR imaging. A few studies have also demonstrated reduction in magnetization transfer ratio (MTR), suggesting microstructural changes in remaining brain tissue. This study assessed the value of measuring MTR in addition to volumetric MR in differentiating patients with AD from control subjects. MA...
متن کاملRegional analysis of the magnetization transfer ratio of the brain in mild Alzheimer disease and amnestic mild cognitive impairment.
BACKGROUND AND PURPOSE Manually drawn VOI-based analysis shows a decrease in magnetization transfer ratio in the hippocampus of patients with Alzheimer disease. We investigated with whole-brain voxelwise analysis the regional changes of the magnetization transfer ratio in patients with mild Alzheimer disease and patients with amnestic mild cognitive impairment. MATERIALS AND METHODS Twenty pa...
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ژورنال
عنوان ژورنال: American Journal of Neuroradiology
سال: 2011
ISSN: 0195-6108,1936-959X
DOI: 10.3174/ajnr.a2812